Initial studies had highlighted a possible link between DTG and neural tube defects birth defects of the brain and spinal cord that cause conditions such as spina bifida in infants born to women using the drug at the time of conception. This potential safety concern was reported in May from a study in Botswana that found 4 cases of neural tube defects out of women who became pregnant while taking DTG.
Based on these preliminary findings, many countries advised pregnant women and women of childbearing potential to take efavirenz EFV instead.
The risks of neural tube defects are significantly lower New data from two large clinical trials comparing the efficacy and safety of DTG and EFV in Africa have now expanded the evidence base. The risks of neural tube defects are significantly lower than what the initial studies may have suggested.
The guidelines group also considered mathematical models of the benefits and harms associated with the two drugs; the values and preferences of people living with HIV, as well as factors related to implementation of HIV programmes in different countries, and cost. Fewer side effects of DTG DTG is hiv and lung cancer treatment drug that is hiv and lung cancer treatment effective, easier to take and has fewer side effects than alternative drugs that are currently used.
DTG hiv and lung cancer treatment has a high genetic barrier to developing drug resistance, which is important given the rising trend of resistance to EFV and nevirapine-based regimens. All of above findings informed the decision to update the guidelines. The new helmintiaza tratament recommendations aim to help more countries improve their HIV policies.
Informed choice is important As for any medications, informed choice is important. Every treatment decision needs to be based on an informed discussion with the health provider weighing the benefits and potential risks.
WHO also stresses the importance of providing information and options to help women make an informed choice. To this end WHO has convened an advisory group of women living with HIV from diverse backgrounds to advise on policy issues related to their health, including sexual and reproductive health.