Cancer hormonal que es, #EAU19. Tratamentul hormonal poate declanșa depresia la bărbații cu cancer de prostată


Politica de confidentialitate Terapia hormonală pentru tratarea cancerului de prostată Terapia hormonală este adesea utilizată în combinaţie cu radioterapia. De exemplu, puteţi face terapie hormonală înainte de a efectua radioterapia pentru a creşte şansele unui tratament de succes.

It is applied in patients expressing tumoral hormone receptors ER - estrogen receptor and PGR - progesteron receptor. It is possible that Tip cancer mamar human epitelial cancer hormonal que es factor receptor 2 to have an influence on the response or resistance to hormonal treatment. This article presents the main classes of drugs used in hormonal treatment and their indication, improvements obtained and future perspectives of research.

Hormonoterapia pentru cancerul de san este un tratament folosit pentru cancerele mamare care sunt sensibile la anumiti hormoni. Cele mai frecvente forme de tratamente hormonale pentru cancerul mamar functioneaza prin impiedicarea hormonilor sa se "lipeasca" sau sa se lege de celulele canceroase sau prin scaderea productiei de hormoni din organism. Celulele canceroase din cancerul mamar ER pozitiv si PR pozitiv au receptori adica niste proteine care se alipesc sau se ataseaza de estrogen, care le ajuta sa se dezvolte.

El este aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor hormonali ER - receptor estrogen şi PGR - receptor progesteron. Cancer hormonal que es posibil ca şi statusul HER2 receptorul 2 al factorului de creştere epidermal uman să aibă influenţă asupra răspunsului şi rezistenţei la tratamentul hormonal.

Articolul are drept scop prezentarea principalelor clase de medicamente folosite în tratamentul hormonal şi a prinicipalelor indicaţii, progrese înregistrate şi perspective de viitor.

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Cuvinte cheie tratament hormonal cancer de sân modulatori selectivi ai receptorului de estrogen inhibitori tratament cu vase oculare aromatază Introduction Hormones are molecules that act like chemical messengers in the human body. Their main circulating path is through the blood stream. Estrogen and progesteron are made in the ovaries in premenopausal women, and in other tissues including fat in postmenopausal women.

Cercetătorii sugerează că pacienții care primesc terapie de deprivare androgenică trebuie monitorizați pentru depresia post-chirurgicală. Acest studiu a fost prezentat în cadrul Congresului Asociației Europene de Urologiecare are loc în perioada martieîn Barcelona.

Apart from their classic role female sex characteristics, pregnancy etc. To determine the hormonal status, tissue from the tumour is needed.

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It can be obtained either by biopsy, or by surgery. Main hormone therapy classes Blocking ovarian function - ovaries are the main production site of estrogen in premenopausal women. Blocking of their function can be achieved by either removing ovaries surgically, or by radiation both being definitive methods cancer hormonal que es, most frequently used cancer hormonal que es, inhibiting their function temporarily by using  gonadotropin releasing hormone GnRH agonists or luteinizing hormone releasing hormone LH-RH agonists.

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Examples: goserelin and leuprolide. The main side effects of these therapies are bone loss, mood swings, depression, and loss of libido. Blocking estrogen production - aromatase inhibitors AI are used to block the production of estrogens from fat and other tissues.

They can be given alone in postmenopausal cancer hormonal que es or in association with ovarian suppression in premenopausal setting. Examples: anastrozole, letrozole - both inactivate temporarily the aromatase enzyme non-steroidal AI - or exemestane, which inactivates the enzyme permanently steroidal AI.

The main side effects are: risk of heart attack, angina, heart failure, and hypercholesterolemia, bone loss, joint pain, mood swings and depression. Blocking estrogens effects - two drugs block the action of estrogen on the breast tumour cells.

Cum ajuta tratamentul cu hormoni (hormonoterapia) in cancerul mamar

Selective estrogen receptor modulating agents SERMs : they bind to the receptor, blocking it, thus preventing the binding of estrogen. Examples: tamoxifen and toremifen. They act like antagonists in some tissues tumour cells and agonists in other uterus, boneinfluencing their safety profile.

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Common adverse cancer hormonal que es risk of blood clots, especially in the lungs and legs, stroke, cataract, endometrial cancer, bone loss in premenopausal women. Other antiestrogen drugs, like fulvestrant: they act similarly to tamoxifen, but without the agonist effect.

Furthermore, after binding to the estrogen receptor, they programme it for destruction. This explains the better safety profile and side effects: gastrointestinal symptoms, elevated liver functional tests, loss of strength and pain Taking into account the medical history of patients and other treatments they are undergoing, we must be careful for cancer hormonal que es.

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For tamoxifen, caution must be taken for patients in treatment with antidepressants from the class of selective serotonin reuptake inhibitors SSRI like paroxetine, which inhibits enzyme CYP2D6.

They slow down tamoxifen metabolization and reduce its effects. Safer alternatives are available, like sertraline, venlafaxine or even considering changing tamoxifen with AI. Treatment protocols Prevention. The same indication for AI is still under investigation 8. There have been several studies investigating this option, mainly using AI.

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The purpose is to ob­tain tumour shrinkage in order to allow breast conserving surgery. Although there are promising results, currently such therapies are not approved for this indication 9. Some studies show that patients with positive ER levels even with low count benefit from at least 5 years of therapy.

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Newer studies extend this period to 7 or even 10 years. In premenopausal patients at high risk cancer hormonal que es age, high grade tumour, lymph node involvmentaromatase inhibitor with associated ovarian suppression or tamoxifen for cancer hormonal que es hormonal que es years can be considered based on SOFT and TEXT trials results.

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