Colorectal cancer cell lines


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In this study the safety usage pattern of wild Pisum fulvum lectin was evaluated on different mammalian noncancerous cell types and the anticancer activity was examined on different cancer human cell lines: colorectal adenocarcinoma Caco-2hepatocellular carcinoma HepG2breast cancer cells MCF7 and laryngeal carcinoma Hep-2 cells. The results revealed that IC50 of the wild lectin on the noncancerous cells ranged from In addition, lectin was more potent against HepG2 cells than the other used cells, with inhibition percentages ranged from The treatment showed Furthermore, HepG2-lectin treated cells showed obvious nuclear condensation after 48 h of treatment with ability to down-regulate the expression of BCL2 and Colorectal cancer cell lines and to up-regulate the expression of Ikab gene.

The results obtained in this research work clearly indicated the Colorectal cancer cell lines fulvum lectin could be a promising potential anticancer agent. Keywords: lectin; Pisum fulvum; Fabaceae; cancer cell lines; antioxidant; anticancer Issue:Volume 70, Issue 4 Pages:

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